### Causes of Ageing and Illness

The link between key systems and associated diseases.

System / Area | Associated Diseases / Conditions
--- | ---
Dermatitis | Cataract, Retinal degeneration
Rheumatoid Arthritis | Oxidative stress contributes to the inflammatory processes and joint damage in rheumatoid arthritis.
Hematometer | Leukemia, Septicaemia, Hyperlipidemia
The Digestive System | Gastritis, Stomach ulcer, Cancer of the stomach, Cirrhosis, Crohn's disease, Pancreatitis
Diabetes Mellitus | Oxidative stress plays a role in insulin resistance and beta-cell dysfunction in type 2 diabetes. Complications such as diabetic nephropathy, retinopathy, and neuropathy are linked to oxidative damage.
Circulatory system/ Respiratory organ | Myocardial infarction, artery hardening, pneumonia, angina
Connective-tissue system | Articular rheumatism, Auto-immune disease, Collagen disease
Respiratory Diseases | Chronic Obstructive Pulmonary Disease (COPD) – oxidative stress from cigarette smoke and pollutants causes lung tissue damage. Asthma – ROS can worsen airway inflammation and hyperresponsiveness.

## Defend Harmful Oxygen Free Radicals

The body utilizes Reactive Oxygen Species (ROS) for several crucial functions when maintained in balance.

01

##### Redox Homeostasis

ROS are involved in maintaining the balance of reduction-oxidation (redox) reactions within cells. This balance is vital for normal cellular function and metabolism.

02

##### Detoxification Support

Certain levels of ROS are required for the activation of antioxidant defenses, which protect cells from oxidative damage.

03

##### Gene Regulation

ROS influence the expression of genes involved in protective responses, such as antioxidant enzymes, heat shock proteins, and DNA repair enzymes.

04

##### Stem Cell Balance

ROS are involved in the regulation of stem cell self-renewal and differentiation.

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